Sir Keir Starmer issued an ultimatum on Tuesday, saying the government would withdraw its offer of thousands of NHS jobs, extra training places, and pay reforms if the walkout wasn't called off within 48 hours.
With no agreement reached, the medics – formerly known as junior doctors – will strike for six days from 7 April.
The British Medical Association's (BMA) resident doctors' committee has maintained the government's pay rise offer does not go far enough to deal with the cost of living.
Sir Keir has pointed out the 3.5% proposal is above inflation and would take their total raise over three years to 35%.
Writing in The Times earlier this week, he said strikes would be "reckless" and damage the NHS.
But the committee's chair, Dr Jack Fletcher, said the government's approach was "extremely disappointing".
Using the offer of more training places as a "pawn" in negotiations was "simply wrong", he said.
"We have consistently maintained that we are willing to postpone industrial action should a genuinely credible offer be provided. This remains the case now, up to, and throughout any period of industrial action," he added.
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A Department of Health and Care spokesperson maintained the deal on offer was "generous".
"Because the BMA resident doctor committee has not agreed to call off these strikes and put an offer to members, we will now not be able to deliver the 1,000 extra training places which the BMA asked for," they said.
"These posts would have gone live this month, but as systems now need to prepare for strikes and more uncertainty, it simply won't be operationally or financially possible to launch these posts in April in time to recruit for this year.
"This won't impact the overall number of resident doctors, and the NHS will be there for patients when they need it."
They said attention must now turn towards protecting patients by minimising disruption during the walkout.
It will be the 15th round of strikes by resident doctors in England since 2023.
Jessica Kent-Hazledine, 33, woke up two weeks after giving birth to her son with little vision in her left eye.
She put that down to tiredness but then lost vision in her right eye, leaving her fearing "the worst".
But a year on, she said her sight is "so much better".
'I thought I'd never see my son again'
Ms Kent-Hazledine, from Cornwall, said: "I was a new mum, not getting much sleep.
"But I thought I should probably get it checked out, and the next thing I knew, I was having an urgent MRI and blood tests. It was all very scary; I was thinking the worst.
"When my vision went in my right eye, too, I was terrified – I thought I wouldn't be able to see my baby grow up.
"I wouldn't be able to see how his face changed or when he took his first steps or had his first day at school.
"I had been a mum for two weeks and was faced with the prospect of not being able to see my son again."
How her sight was restored
After trying out some other treatments, medics arranged for a plasma exchange for Ms Kent-Hazledine, which was carried out by a new service run by NHS Blood and Transplant (NHSBT) in the South West.
In the procedure, a patient's plasma, the liquid component of blood that helps transport blood cells, nutrients and hormones around the body, is removed from the bloodstream and replaced with donor plasma.
This helped prevent the antibodies in her blood from attacking and damaging the protective layer around the nerve fibres in her eyes.
Overall, she had five exchanges but said things began to improve by the third.
Now she can see clearly out of her right eye and has around 75% sight in her left one.
'It felt like magic'
Ms Kent-Hazledine said: "By the fifth [exchange], I felt pretty much back to myself; it felt like magic.
"It's been almost a year now, and my sight is so much better. I still have some blurring in half of my left eye, but I can look after my son and live an independent life, which I was worried I wouldn't be able to."
Ms Kent-Hazledine was the first person in Cornwall to use the NHSBT's new therapeutic apheresis service (TAS), which is working with four hospitals in the region.
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She said she felt "so lucky" to have had the treatment and was grateful to those who donated blood and plasma – encouraging others to do the same.
"I don't think people realise just how much good donation can do – we all know blood can be used in emergencies, but it can also be used to help so many people like me," she said.
"I'd urge absolutely everybody who is eligible to go and give blood or plasma – and thank you to those who already do."
Laura Ann Aime, 17, went missing 51 years ago after she left a party alone. A month later, her body was found by hikers on the side of a highway in American Fork Canyon.
She was bound, beaten and without clothing.
Bundy had "verbally acknowledged" his culpability leading up to his execution in Florida in 1989 - but the case remained open until they could be certain.
US authorities decided to revisit Ms Aime's case by examining evidence from the scene to take advantage of the "evolution of criminal forensic science".
"Existing evidence was submitted to the Utah Bureau of Forensic Services so we could utilise the various forms of advanced forensic sciences and professionals," the sheriff's office said on Wednesday.
"The results were magnificent as they confirmed irrefutably that DNA evidence recovered from Laura's body verified the existence of DNA belonging to Bundy."
Bundy has been linked to at least 30 women and girls' deaths across several states in the 1970s, making him one of America's worst serial killers.
"In the days and hours leading to his execution, Bundy verbally acknowledged his culpability in the death/disappearance of Laura and others," the sheriff's office said.
"At the time of his admission, the Utah County Sheriff's Department and Utah County Attorney's Office both declined to accept Bundy's verbal accountability for Laura's homicide, as the open Utah County case was unable to satisfactorily convict Bundy based upon the evidence in possession and with the available investigative sciences for the time."
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"Laura Aime is the quintessential daughter of Utah County," Utah County sheriff's sergeant Mike Reynolds said.
"We felt the pain the family feels when she was taken. We felt the pain that you felt this whole entire time, and we've had the desire to deliver to you some type of healing, we can't really say closure."
Authorities said Ms Aime may have been kept alive for days or even more after her abduction.
"Laura is remembered by her family and friends to be a tall, beautiful, outgoing free spirit who enjoyed outdoor activities and shared a passion for riding horses, hunting, and caring for her several siblings," the sheriff's office said.
"Her family said that Laura was one who found joy in everything she did, making the most of her time with her family. Laura's younger siblings told stories of her abundant compassion and warmth for her family."
Officers were called to reports of a man with a knife at Red Lion Place, Plumstead, at 8.50am.
Emergency crews found the woman with serious injuries and she was taken to hospital where she died.
Another man was also threatened with a knife but was not hurt, the Metropolitan Police said.
A man in his 60s attended a police station at 9.10am and was arrested on suspicion of murder.
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He was taken to hospital by officers, where he is receiving treatment for non-life-threatening injuries.
It is believed the suspect and the woman who died were known to each other. Officers are not looking for any further suspects.
Detective Inspector Dean Grice, who is leading the Met's investigation, said it was "a deeply tragic incident", adding "our thoughts remain firmly with the victim's family during this difficult time".
Residents will see an increased police presence in the local area, the Met said.
Detective Superintendent James Derham, who leads policing in the local area, said: "At this stage, we believe that this was an isolated incident and I want to reassure the community that there is no wider risk to the public."
Mr Trump's presence in the US's highest court on Wednesday marked a historic first for a sitting president.
The court had been considering the Trump administration's appeal of a lower court ruling that struck down the US president's executive order scrapping birthright citizenship for babies born to illegal and temporary migrants.
The Trump administration has argued that birthright citizenship, which is enshrined under the 14th amendment of the US constitution, has been exploited by immigrants to remain in the US.
Mr Trump, who wore a red tie and dark suit, sat in the first row of the public section of the courtroom.
After listening to the opening arguments for just over an hour, Mr Trump left the hearing.
The more than two-hour-long hearing heard arguments from US solicitor general John Sauer, representing the Trump administration, and American Civil Liberties Union, which has challenged the executive order.
Mr Sauer told the court "unrestricted birthright citizenship contradicts the practice of the overwhelming majority of modern nations".
"It demeans the priceless and profound gift of American citizenship," he said.
"It operates as a powerful pull factor for illegal immigration and rewards illegal aliens who not only violate the immigration laws but also jump in front of those who follow the rules."
Mr Sauer argued a caveat in the 14th amendment that says birthright citizenship will be granted "subject to the jurisdiction thereof", should be extended to babies born to illegal or temporary immigrations.
The phrase has historically been used to exclude the children of ambassadors and enemies during an invasion.
Conservative Chief Justice John Roberts told Mr Sauer the argument was "quirky".
"I'm not quite sure how you can get to that big group from such tiny and sort of idiosyncratic examples," he said.
ACLU lawyer Cecillia Wang, who argued on behalf of the challengers, told the justices Mr Trump's order was
unlawful.
"Ask any American what our citizenship rule is and they will tell you, 'Everyone born here is a citizen, alike'," she said.
"That rule was enshrined in the 14th amendment to put it out of the reach of any government official to destroy."
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Ms Wang also referenced a 1898 case, known as Wong Kim Ark, which set the precedent that the 14th amendment granted birthright citizenship to those born on US soil, including the children of foreign nationals.
"When the government tried to strip Mr Wong Kim Ark's citizenship on largely the same grounds they raised today, this court said no," she said, adding "this court held that the 14th Amendment embodies the English common law rule: Virtually everyone born on US soil is subject to its jurisdiction and is a citizen."
A definitive ruling on the executive order, which Mr Trump signed on the first day of his second term to bring down immigration, is expected early in the summer.
The 14th amendment was ratified in 1868 in the aftermath of the Civil War, which ended slavery in the US and overturned a 1857 Supreme Court decision that meant people of African descent could never be American citizens.