The 32-storey Space Launch System (SLS) rocket is set to blast off from the Kennedy Space Centre in Florida on Wednesday, sending four astronauts on a 10-day flight ending with a splashdown in the Pacific Ocean.
At a briefing by NASA on Monday, Emily Nelson, chief flight director, said teams in mission control and crew members are "ready to go".
Artemis II: Everything you need to know
The Artemis I mission didn't have any astronauts on board but was successfully sent into orbit around the moon in November 2022.
Artemis II takes it a step further with a crew on board, but it won't be until Artemis III that astronauts will actually land on the moon.
The US space agency hopes to use Artemis to build a base camp on the surface and potentially use it to get a human to Mars.
After a liquid hydrogen leak during a practice launch in February, NASA was forced to delay the operation until Wednesday.
At 98m tall, the SLS rocket is roughly the height of Parliament's Elizabeth Tower, which houses Big Ben. Not since Apollo 17 in 1972 have humans touched down on the moon's surface.
The astronauts on board are NASA's Reid Wiseman, Victor Glover and Christina Koch, plus Jeremy Hansen of the Canadian Space Agency.
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British astronaut Major Tim Peake has said Europe, including the UK, is heavily involved in the Artemis programme.
"We were there on Artemis I... we built the European service module which powers the Orion spacecraft that provides all the electrical power, the life support systems, the propellant," he said.
NASA has the first six days of April to launch Artemis II before standing down until the end of the month.
The medics – formerly known as junior doctors – are planning to walk out for six days from 7 April, just after the Easter bank holiday weekend.
Politics Hub: Follow the latest
It will be the 15th round of strikes by resident doctors in England since 2023, in an ongoing row over pay and jobs.
Sir Keir has condemned the planned action as "reckless" and given them 48 hours to reconsider.
Writing in The Times, he said the British Medical Association's (BMA) resident doctors' committee had rejected a "historic deal" that would have delivered "another above-inflation pay rise this year" of 3.5%.
It would bring the total pay rise over three years to 35%, the prime minister added.
'Wrong decision'
He said the government's proposal would also have delivered reforms to pay progression to reward doctors as they gained experience and responsibility, reimbursed the cost of Royal College exams, and provided up to 4,500 extra speciality training places over the next three years.
The measures "are the result of months of collaboration with the BMA, who engaged constructively throughout", the prime minister said.
"That is why walking away from this deal is the wrong decision. It is a reckless decision. And doing so without even giving resident doctors themselves the chance to vote on it makes it even worse," he wrote.
Sir Keir warned each round of strikes costs the NHS £250m paying for cover and would threaten the progress he said Labour had made in improving wait times for patients.
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The BMA's resident doctors' committee has defended rejecting the deal, citing the cost of living and expectations that inflation will rise as a result of the Iran war.
Chairman Jack Fletcher said in a statement last week: "We cannot ignore that, thanks to global events, economic indicators now point to years of greatly increased inflation.
"We are simply not going to put an offer to doctors that risks locking in further erosion of pay at a time when doctors continue to leave the UK for other countries."
He insisted the committee was still "willing to negotiate".
The Tories have said the continued threat of strikes despite pay rises already handed out by the government proves "stronger action is needed", namely a ban on doctors' strikes.
Molly, not her real name, has chosen to speak publicly after the attack in 2022 by a man who was wrongly given access to her Berkshire hotel room.
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Attacker Kyran Smith, who had falsely claimed to be her partner, was jailed in February for seven and a half years.
The hotel was forced to apologise for initially offering the victim £30 as compensation, though it has since acknowledged the response was "inappropriate".
Since the conviction, Molly has met with the hotel CEO, Jo Boydell, and a number of Labour MPs who are leading a campaign for tightened security across the sector.
But she has told Sky News she is "frustrated" by Ms Boydell's handling of the issue, citing "very slow progress" and a lack of accountability.
"It has changed my opinion on staying in hotels on my own," she added.
"It doesn't matter what personal details anyone has about anyone; that's still not an OK thing to do. Even if it was my husband or partner, did that give them consent just from showing a picture of me?"
Travelodge boss 'desperately sorry'
Travelodge's Ms Boydell said the incident had left her "absolutely horrified".
Responding to the victim's criticism of how it had been handled, the chief executive said she was "desperately sorry for what happened to the survivor and really sorry for the way that it took us so long to actually escalate that and handle that properly in the way that we are now".
PM ramps up pressure
In response to the public outcry, Travelodge said it has made immediate changes to its security policy, and no extra room keys will be permitted without the explicit consent of the guest on the booking.
Ms Boydell has also met with MPs, including representatives of Sir Keir Starmer and Rachel Reeves, to discuss what went wrong and how hotels can be safer places for women.
But since then, the boss has refused to engage with a larger group of MPs, which has drawn criticism from the prime minister himself, who urged Ms Boydell to "seriously" consider the invitation for wider engagement.
"It has taken me aback," Molly said of Sir Keir's intervention.
"I'm genuinely very happy that they're taking it seriously. My frustration is purely with the hotel, how they've dealt with everything."
'Apologies only go so far'
MPs have expressed similar frustrations. Labour MP and ex-police officer Matt Bishop is one of two MPs looking at how security in hotels can be more consistent going forward.
"This case should have been a moment for leadership and accountability – but instead, it risks reinforcing the very concerns that have been raised from the outset," he told Sky News.
"I am also quite shocked that the survivor has had to wait for three and a half years, a criminal court case, a media headline-breaking story and a letter from parliamentarians for this to happen. It is not good enough to just say that you were not aware – what has changed to ensure this never happens again?"
Fellow MP and campaigner Jen Craft said: "It is a step forward to see the CEO finally beginning to face up to these serious issues publicly, but this has taken far too long – and only after the victim has told her story so bravely.
"Apologies only go so far, and it's clear there is still a long way to go for Travelodge to reassure guests about safety in their hotels.
"The CEO must explain how this catastrophic failure in safeguarding was not escalated at the time and meaningfully engage with a wider group of MPs about new measures to tackle violence against women and girls in their hotels."
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Travelodge maintains it is taking the situation with the "utmost seriousness" and has commissioned an independent review into what happened.
A spokesperson added: "We have offered that all MPs interested in this important issue can feed into the independent review in writing so their contributions can be fully taken into account.
"Our immediate priority is to progress this important work at pace, progressing our independent review and further strengthening our processes."
Sky News understands the chain also wants to work with MPs about any legislative change, which is currently being explored.
After the Easter break, a cross-party group of ministers plans on meeting with hotel bosses to discuss options, with victims' minister Alex Davies-Jones saying "nothing is off the table".
The decision, agreed with the King, comes after their father, Andrew Mountbatten-Windsor, was arrested on suspicion of misconduct in public office last month.
He was taken into police custody and later released under investigation on suspicion that he shared sensitive information with late sex offender Jeffrey Epstein when he was UK trade envoy.
The former prince has repeatedly denied any wrongdoing in connection with Epstein.
Beatrice and Eugenie – who have been named among the millions of Epstein-related documents released by the US justice department – have made alternative plans for this Sunday, according to PA.
The King, Queen and other members of the family – including the Prince and Princess of Wales – are set to attend an Easter Matins church service at St George's Chapel, Windsor Castle.
It is understood Beatrice and Eugenie will be at future family events.
The Epstein files
Beatrice's and Eugenie's names appear in the files in emails between Epstein and their mother, Sarah Ferguson.
Being mentioned in the files is not evidence of wrongdoing.
One email exchange suggested Ms Ferguson took her daughters to see Epstein in the US just days after he was released from prison for child sex crimes in 2009. They were 19 and 20 at the time.
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Like her ex-husband, Ms Ferguson has lost several titles in recent months as more revelations about Epstein and his past associates have emerged. Last week, she lost the freedom of the city of York.
Beatrice and Eugenie have kept their princess titles.
Their father has been living at Sandringham since leaving Royal Lodge in Windsor at the start of February.
The French-Canadian singer revealed she had the rare and incurable disease in 2022 and was forced to cancel a world tour.
She made an emotional comeback at the opening ceremony of the Paris Olympics in 2024.
The upcoming concert series will also take place in the French capital and will be her first in almost six years.
In a post on Instagram on her 58th birthday, she described the plans for 10 gigs as the "best gift of my life".
"I have to tell you something very important," she said in a video message.
"Over these last few years, every day that's gone by, I felt your prayers and support, your kindness and love; even in my most difficult times, you were there for me.
"You've helped me in ways that I can't even describe, and I'm truly so fortunate to have your support. I've missed you so much. And that brings me back to my birthday, actually. So this year, I'm getting the best gift of my life.
"I'm getting the chance to see you, to perform for you once again in Paris, beginning in September this year."
Dion, who is best known for hits including My Heart Will Go On, Think Twice and It's All Coming Back To Me Now, said she was "feeling good" and "excited" about the shows – and "a little nervous" too.
She revealed she had been "singing again, even doing a little bit of dancing".
"I love it so much," she added.
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Her Instagram post coincided with a series of videos displayed under the lights of the Eiffel Tower on Monday night promoting her announcement.
A screen projected onto the tower said: "Paris, I'm ready. Celine Dion."
The five-time Grammy winner will perform at the city's La Defense Arena between 12 September and 14 October.
Tickets go on sale next week.