The government had already announced its intention to slash the headcount across both NHS England and the Department of Health by around 18,000 administrative staff and managers, including on local health boards.
The move is designed to remove "unnecessary bureaucracy" and raise £1bn a year by the end of the parliament to improve services for patients by freeing up more cash for operations.
NHS England, the Department of Health and Social Care, and the Treasury had been in talks over how to pay for the £1bn one-off bill for redundancies.
It is understood the Treasury has not granted additional funding for the departures over and above the NHS's current cash settlement, but the NHS will be permitted to overspend its budget this year to pay for redundancies, recouping the costs further down the line.
'Every penny will be spent wisely'
Chancellor Rachel Reeves is set to make further announcements regarding the health service in the budget on 26 November.
And addressing the NHS providers' annual conference in Manchester today, Mr Streeting is expected to say the government will be "protecting investment in the NHS".
He will add: "I want to reassure taxpayers that every penny they are being asked to pay will be spent wisely.
"Our investment to offer more services at evenings and weekends, arm staff with modern technology, and improving staff retention is working.
"At the same time, cuts to wasteful spending on things like recruitment agencies saw productivity grow by 2.4% in the most recent figures - we are getting better bang for our buck."
Mr Streeting's speech is due to be given just hours after he became entrenched in rumours of a possible coup attempt against Sir Keir Starmer, whose poll ratings have plummeted ahead of what's set to be a tough budget.
Mr Streeting's spokesperson was forced to deny he was doing anything other than concentrating on the health service.
Read more from Sky News:
Russian troops in Mad Max-style video
Shamima Begum 'should be repatriated'
He is also expected on Wednesday to give NHS leaders the go-ahead for a 50% cut to headcounts in Integrated Care Boards, which plan health services for specific regions.
They have been tasked with transforming the NHS into a neighbourhood health service - as set down in the government's long-term plans for the NHS.
Those include abolishing NHS England, which will be brought back into the health department within two years.
Watch Wes Streeting on Mornings With Ridge And Frost from 7am on Sky News.
The US has reported carrying out 14 strikes since September on boats near the Venezuelan coast, with the number of people killed rising beyond 70.
Downing Street did not deny reporting by CNN that the UK is withholding intelligence from the US to avoid being complicit in military strikes it believes may breach international law.
Britain controls several territories in the Caribbean, where it bases intelligence assets, and has long assisted the US in identifying vessels suspected of smuggling narcotics.
That information helped the US Coast Guard locate the ships, seize drugs and detain crews, CNN cited sources as saying, but officials are concerned the Trump administration's actions may be illegal.
The intelligence-sharing pause began more than a month ago, CNN reported, quoting sources as saying Britain shares UN human rights chief Volker Turk's assessment that the strikes amount to extrajudicial killing.
The reports could provide an awkward backdrop for a meeting between Foreign Secretary Yvette Cooper and her US counterpart Marco Rubio, expected on Wednesday at the G7 foreign ministerial summit in Canada.
A Number 10 spokesman did not deny the move when asked about the pause in intelligence sharing.
"We don't comment on security or intelligence matters," the official said in response to repeated questions.
"The US is our closest partner on defence, security and intelligence, but in line with a long-standing principle, I'm just not going to comment on intelligence matters."
He added that "decisions on this are a matter for the US" and that "issues around whether or not anything is against international law is a matter for a competent international court, not for governments to determine".
A Pentagon official told CNN the department "doesn't talk about intelligence matters".
Read more:
US 'likely jammed GPS signals' off Venezuela
'We will treat them EXACTLY how we treated al Qaeda'
On Monday, US war secretary Pete Hegseth said on X that the previous day, "two lethal kinetic strikes were conducted on two vessels operated by Designated Terrorist Organizations".
He said: "These vessels were known by our intelligence to be associated with illicit narcotics smuggling, were carrying narcotics, and were transiting along a known narco-trafficking transit route in the Eastern Pacific.
"Both strikes were conducted in international waters and 3 male narco-terrorists were aboard each vessel. All 6 were killed. No U.S. forces were harmed."
The United Nations human rights chief has described the US strikes on alleged drug dealers off the coast of South America as "unacceptable" and a violation of international human rights law.
Venezuela says they are illegal, amount to murder and are aggression against the sovereign South American nation.
Shouting angrily, crowds demanded access to the compound where thousands of delegates from nations around the world are attending this year's UN convention in Belem, Brazil.
Some waved flags with slogans calling for land rights or carried signs, saying "our land is not for sale".
An indigenous leader from the Tupinamba community, found near the lower reaches of the Tapajos River in Brazil, told Reuters they were upset about ongoing development in the Amazon rainforest.
Security guards pushed the protesters back and used tables to barricade the entrance.
A Reuters witness saw one security guard being rushed away in a wheelchair while clutching his stomach.
Another guard with a fresh cut above his eye told the news agency he had been hit in the head by a heavy drumstick thrown from the crowd. Security confiscated several batons.
The protesters dispersed shortly after the clash.
Security guards later allowed delegates to exit the venue, having earlier asked them to move back inside until the area was clear.
A UN spokesperson said two security staff were injured during the clashes.
Read more from Sky News:
Sally Kirkland dies aged 84
UK stops some intel sharing with US
COP30, which started on 10 November and ends on 21 November, comes at a precarious time for climate action.
The conference has been met with controversy over its location in Belem, on the outskirts of the Amazon.
Brazil's President Luiz Inacio Lula da Silva has highlighted indigenous communities as key players in COP30 negotiations.
Dozens of indigenous leaders arrived earlier this week by boat to take part in the talks and demand more say in how forests are managed.
The report, by an independent commission, said the current policy of leaving such women, men and children in limbo was "unsustainable" and risked turning the detention camps in northeastern Syria into "Britain's Guantanamo".
This is a reference to the notorious American detention facility in Guantanamo Bay, Cuba, that was used to imprison al Qaeda suspects indefinitely.
The Independent Commission on UK Counterterrorism warned that conditions at the Syrian camps, including Al Hol and Al Roj, "constitute inhuman and degrading treatment".
It said forcing British-linked people to live in such facilities instead of allowing them to return home was "inconsistent" with the UK's international human rights obligations.
The exact number of British citizens, as well as individuals like Begum, who had her citizenship revoked because she joined Islamic State (IS), stranded in the camps is not clear.
But estimates put the total figure at between 50 and 70, the majority of them women, and between 12 to 30 children, half of whom are under the age of 10.
There is a particular obligation of the British state to protect children from harm.
"The government should facilitate the voluntary repatriation for British nationals, including those deprived of British nationality," the commission said.
"It should appoint a special envoy to oversee repatriation and inform returnees of the likelihood of prosecution."
The report said that the UK was an "outlier" in its policy towards UK-linked citizens who joined Islamic State and are detained in camps.
Termed "strategic distance", the British approach involved stripping people of their citizenship, limiting consular assistance and helping to fund the Kurdish guards who man the detention camps to ensure they remain stranded.
By contrast, the US, Canada and several European states have brought their citizens who joined Islamic State home.
"Pressure from the US government, which has called for all states to take back their nationals, the change in the Syrian regime, and as other states repatriate, the prospect of what was referred to as 'Europe's Guantanamo' becoming 'Britain's Guantanamo', may force the government to begin returns," the commission said.
The report cited research that found the balance of risk favoured repatriating British-linked people rather than leaving them stranded in Syria and open to potential further radicalisation.
"As escapes from camps are likely to lead to some returns to the UK, an organised programme of return, rehabilitation and integration is the best long-term option for managing risk," the commission said.
It listed tools that could be used to manage returns and limit the risk to public safety, including preventing returnees from travelling, putting them under investigation and enrolling them in deradicalisation programmes.
Shamima Begum, now 26, is the most high-profile detainee in the Al Roj refugee camp.
She lost an appeal against the removal of her British citizenship last year.
Begum travelled to Syria in 2015, aged 15, with two schoolfriends. She married an Islamic State fighter soon after her arrival. They had three children, but none survived.
She has been stranded in the camp since 2019.
Read more:
Ex-IS brides and their children desperate to go home
British girl returns to UK from IS detention camp in Syria
As well as recommendations on what to do about British-linked citizens detained in Syria, the report focused on how to improve counterterrorism measures in the UK.
Most significantly, it found that the UK's Prevent counter-terrorism strategy "is no longer keeping the country safe" and needs a "radical overhaul".
Warning: This story contains references to suicide.
In a powerful interview with Sky News, the Oscar-nominated, BAFTA-winning actor and director, who grew up in care, said Britain's care system needs to be "completely rethought".
It comes after a Sky News documentary, A Girl Called Nonita, told the story of 18-year-old Nonita Grabovskyte, who died in the care of the state following a catalogue of failures by those responsible for her care.
Nonita took her own life on railway tracks in December 2023, just two weeks after her birthday. She had previously told doctors and social workers that she intended to kill herself as soon as she turned 18. But nothing was done to prevent her death.
"I was a child of the state, just like Nonita," Morton told Sky News.
"I was put in care at birth until I got the letter to say I was no longer the council's responsibility. I was kicked out at 16 and put into a homeless hostel."
After spells of homelessness, she found a local TV actors' workshop and managed to secure roles that would eventually lead to Hollywood.
But she says she has never forgotten her childhood, which saw her in and out of children's homes and foster families.
"The lack of care historically is shocking," she said. "But the lack of care today is worse. Back then, it felt like there was at least some comeuppance.
"The system now is not fit for purpose. It needs root and branch reform. It needs to be completely rethought."
The data shows a sharp rise in deaths among care leavers - young adults who have aged out of the care system and are expected to live independently, often with little or no support.
The Department for Education only began collecting data for care leavers aged 22 to 25 in 2023, meaning the true scale of deaths over the past decade is likely to be far higher.
Morton says councils should be held more accountable for the deaths of children in their care, especially if local authority failings contributed to deaths.
'State manslaughter'
"A failure to care has massive consequences," she told Sky News. "And the consequences are that people like Nonita die. I believe that that is a kind of state manslaughter.
"And individuals who fail to do their job properly should be in a dock."
Education Secretary Bridget Phillipson has told Sky News that deaths of care-experienced young people should "shame us all".
All deaths of children in the care of the state must be reported to the government via the Child Safeguarding Incident Notification Scheme.
But there are doubts as to whether all deaths are being reported.
'Shames us as a country'
Ms Phillipson told Sky News she has asked officials to urgently review the process to check for underreporting.
"I'm concerned about serious incident notifications - about making sure we're receiving all notifications of such incidents taking place," she said.
"Because it's only if we know what's happening, if we fully understand what's going on in the lives of children, that we as a government, as a country, can provide the support they need."
Read more from Sky News:
PM vows to fight plots to oust him
Thousands of NHS staff to lose jobs
Ms Phillipson added: "It shames us all as a country that we so badly fail many of the most vulnerable children who've experienced such appalling trauma and abuse in their early lives.
"I read every single notification personally - and it always stays with you. Every case is a child or young person who deserved better."
If you have been affected by any of the issues raised in this story, help, and support is available. You can call Samaritans free on 116 123 anytime day or night. You can also email jo@samaritans.org or visit www.samaritans.org to find support online.