It comes amid scrutiny over her claim to be a lawyer and bad reviews of her first press conference.
Donald Trump said on Friday he'd told her to reconsider the role, and soon after a senior White House official confirmed to NBC News that she was out of a job.
The US president said Ms Zacharia had been treated "so nasty" by some sections of the media and he wanted her to be "happy".
He said she had told him the job was "a lot tougher", but he would "let her make that decision" [on whether to resign].
"She's a nice person, a great person, and she's been treated roughly," the president told reporters.
He said he'd asked her if she wanted to "really live like this" as the media would probably not "ease up".
Just days ago, the president said he thought his new press chief would be "terrific" but on Friday admitted "maybe it's not for her".
Ms Zacharia, who received a law degree from California's Pepperdine University, was in the spotlight after having repeatedly referred to herself as a lawyer in interviews.
She admitted failing the bar exam in the state and said she never tried again as she was moving to China.
The 42-year-old said she had been careful not to call herself an "attorney at law" - which would indicate she was qualified to practise.
Ms Zacharia told Fox News she had consulted "legal professionals" who told her it was acceptable to call herself a lawyer as she attended a "reputable law school" and had "legal experience".
She also said in separate comments she had "practised international transaction law, with all the appropriate credentials" while living in China with her husband.
Doubts were also raised over that claim however, as the country requires Chinese citizenship to pass the bar exam.
Gaffe during shaky debut
Ms Zacharia's first time taking questions on behalf of the Trump administration was only on Tuesday, when she spoke for an unusually short 15 minutes and took just three questions.
She spent more than half that time reading pre-prepared remarks.
Asked by Fox News if the US had stopped sharing intelligence with Ukraine, she told the reporter she would "have to get back to you on that".
There was also an embarrassing slip when she referred to "my president" instead of "my husband".
The mother-of-four first became known publicly as a conservative commentator and often appeared on Fox News and also right-wing media.
The long-time Trump loyalist worked for the company behind his Truth Social platform, and briefly in the Department of Homeland Security press office.
Ms Zacharia always had a tough act follow.
Her 29-year-old predecessor Karoline Leavitt, who had been in the job since January 2025, was widely praised.
More from Sky News:
What happened to Trump's previous press secretaries?
In 2017, during President Trump's first term, communications director Anthony Scaramucci lasted 10 days in the job - or six days if counting from his official start date.
Posting on X, he said it was a lucky escape for Ms Zacharia.
He posted: "Dear @katiezacharia ---- speaking as the world's leading expert on short White House tenures: turn off the news and go enjoy your family.
"In time you'll realize that the Universe did you a major favor."
William Chapman, 24, died after entering the enclosure at the Doncaster attraction last Saturday.
Yorkshire Ambulance Service Trust said it believed two staff had accessed or tried to access "incident/medical information... without a legitimate reason to do so".
It said the concern had been identified following "proactive audits", and a investigation into the full circumstances was under way.
The Information Commissioner's Office (ICO) has been informed and the trust said it would keep Mr Chapman's family up to date.
An inquest into the incident opened on Thursday and heard he died from "multiple traumatic injuries" following contact with the five-year-old male Siberian tiger called Altai.
It was told he had previously been diagnosed with schizophrenia and suffered bouts of psychosis. His family have expressed concerns about his contact with mental health services prior to his death.
A full inquest is scheduled for March.
There have been other instances of NHS staff accessing medical information on high-profile cases without a legitimate reason.
A child attacked by a crocodile at a zoo in June had their records accessed by dozens of staff.
Southport attack survivor Leanne Lucas had her records inappropriately accessed and was not told until two years later. Eleven staff were also sacked for accessing the records of the 2023 Nottingham attack victims.
In September, 10 workers were removed from duty after being suspected of accessing the records of three-year-old Noah Woods, who was found dead in a Suffolk lake.
More from Sky News
Teen hitman who flew to UK to commit murder jailed
Briton fined for causing death of two-year-old son
The head of the NHS warned staff last month that they faced immediate suspension if caught.
A Sky News investigation found nearly 3,000 data breach cases had been investigated by the NHS since 2021, many involving ordinary patients. Just over 400 were referred to the ICO.
Some 67% of cases resulted in minor punishment - such as an informal, verbal, or written warning, or no further action.
But of the 134 who responded to our Freedom of Information requests, only 54 said they routinely looked for potential breaches.
Romanian Stanislav Carpiuc, 28, was found guilty of carrying out a string of arson attacks on a car and properties linked to the former prime minister earlier this year.
The Old Bailey heard that he and Ukrainian Roman Lavrynovych, 22, acted on the orders of a Russian-speaking Telegram contact called "El Money".
On Friday, the Home Office said that Carpiuc, who was sentenced to two years in prison, had been removed from the UK.
A Home Office spokesperson said: "This was an abhorrent attack, and the conviction and imprisonment of these men should send a clear message to anyone blinded by the promise of money from strangers.
"You will be caught and face severe consequences. This individual has now been deported from the UK."
Anyone who is deported from the UK is subject to a ban on re-entering the country.
During the trial, the court heard that a Toyota RAV4, which once belonged to the prime minister, was set alight in Kentish Town, north London, in the early hours of 8 May last year.
On 11 May, a fire was started at the door of an Islington flat, where Sir Keir had previously lived, while his constituency home was attacked on 12 May 2025.
The prime minister's sister-in-law, Judith Alexander, who moved in after Sir Keir entered Downing Street, said she heard bangs and saw smoke as her partner and daughter slept.
More from Sky News:
White House spokesperson leaves after a week
Is Zelenskyy Trump's 'scapegoat'?
The court also heard "El Money" offered Lavrynovych £3,000 in cryptocurrency if the blazes were filmed and were reported in the news.
Carpiuc, who had a short-lived modelling career, supported and encouraged his friend, the court heard, and was going to help him convert the promised payment into cash.
Johannes Natland, 19, agreed to shoot an unknown target in exchange for €25,000 (£21,000).
He was recruited by the Sweden-based Foxtrot network, which has been sanctioned in the US and the UK over violence against Jewish and Israeli targets on behalf of the Iranian regime.
Natland was directed to stashes of cash, guns and bullets by a fixer in the UK, before being arrested by armed counter-terrorism police at a hotel in Huddersfield, West Yorkshire, on 19 March last year.
During the arrest, he formed his hands into an imaginary gun and pretended to shoot officers, who found two guns, live bullets and £2,000 in cash.
Natland admitted possession of the two guns and ammunition but denied conspiracy to murder, telling a jury: "I'm not no cold-blooded professional hitman."
He was found guilty at the Old Bailey at a retrial after the first jury failed to agree on a verdict.
Natland, wearing a pale blue shirt, smiled at his family, including his parents and brother and sister, in the public gallery as he came into Woolwich Crown Court to be sentenced, while his mother blew kisses as he was taken down to the cells.
Sentencing Natland the judge, Mrs Justice Cheema-Grubb, told him: "At the heart of this case is the stark fact you agreed to assassinate another human being, a stranger to you, in a foreign country.
"You knew nothing about the person's life or circumstances.
"You were just 18 years old when you placed yourself in readiness to murder for money.
"The commission was for the Foxtrot network and arranged online through social media platforms.
"But the idea of being involved in such an endeavour thrilled your immature personality, which was no longer tethered to the strong family network and social network you had grown up in, due to teenage drug addiction."
Gang linked to murders across Europe
The court heard how the talented footballer was recruited by the Foxtrot gang, led by Rawa Majid, known as the Kurdish Fox, days before he flew to Manchester Airport on 17 March last year, when he was aged just 18.
The group has been linked to around 35 murders in Europe as well as other violent attacks and firebombings, using violence-as-a-service tactics.
The gang advertises violent assignments on social media apps, such as Snapchat, Telegram and Signal, targeting children as young as 12 in groups with thousands of members with names like "Samurai kids".
Natland was first put in touch with a member of the gang by a boy he met in a care home and was passed on to a recruiter using the online alias Generalen, another teenager from the same city as Natland.
Generalen has been convicted and jailed in Norway over his involvement in the plot - as well as two murders in Sweden and two other attempted murders.
He was acting for a higher-level recruiter, "Agent 47" - named after a character in the Hitman videogame - who is believed to be Ali Shehab Ahmed, 22, who was arrested in Iraq last year.
'I'm going on a crazy mission'
In messages shown in court, Agent 47 told Generalen: "Brother, sort an assassin abroad. Urgent. Europe."
Generalen asked: "How much is in the pot?" and Agent 47 replied: "25k euro."
In a message on 15 March last year, Natland asked Generalen, "Who is to be shot?" before telling his girlfriend he was "going on a crazy mission".
Agent 47 put Natland in touch with a facilitator in the UK, known as "1", who directed him to a stash of cash hidden under a bridge.
He used the money to pay for a room for three nights at the Briar Court Hotel before being sent another video and map showing the route to the base of a tree, where he picked up the guns and ammunition.
On 18 March, he bought three pairs of workman-style black and orange gloves which he wore to handle the weapons - an antique pistol, a semi-automatic handgun and 12 live bullets - in videos filmed on his phone.
He was also sent the location of a stolen car, while Agent 47 told him: "We have much to do tomorrow."
Natland told the jury he initially thought the plot was a "joke", then planned to shoot himself in the foot because he thought he or his family may be killed if he backed out.
"When I realised this is real and these guys are expecting me to go to England and shoot someone, I'm in a bit of a pickle," he said.
'My son could never kill anyone'
Natland's mother, who does not want to be named or pictured, previously told Sky News prosecutors had portrayed her son as a "monster", but she believes he is a victim of "human trafficking".
"When it can happen to us, it can happen to anyone," she said.
"I know that my son could never kill anyone. He's just not got it, he's not that kind of person, it's totally out of character.
"He's never shown any way of being that should make him a hitman or a killer... It would never happen. No one knows him better than I do."
More from Sky News:
British father fined over death of son in Cyprus
Follow live updates from Russell Brand's trial
Paul Hynes KC, defending, said Natland had been a "popular, successful student and sportsman" until his "tragic descent" into using drugs, which "exacerbated if not created" significant mental health issues.
He said his arrest and convictions have been a "chastening, humbling and frightening" experience and Natland is not the young man who replied to the message, "saying is anyone up for murder for money?".
Met Police Commander Helen Flanagan, the head of Counter Terrorism Policing London, said Natland was arrested "just hours before he was due to carry out an assassination".
"The intended target of this specific assassination has never been identified, and we found no evidence of any direct link to Iran in this case," she said.
"However, as recent events have shown, CTP will seek to proactively disrupt any attempts by hostile states to carry out criminal acts in the UK."
Natland's Norwegian lawyers said they will work to have him transferred to Norway to serve his sentence as quickly as possible.
"Our priority now is to bring him home," said Farid Bouras.
"Whatever we conclude about the sentence, the aim is clear: he is to serve his sentence in Norway, close to his family, in a system designed to bring young people back into society."
Joshua Foster, 37, had earlier pleaded guilty to a charge of causing death through a reckless, rash or dangerous act.
Foster, an auditor from Essex, was sentenced at Paphos District Court on Friday over the death of the toddler while on a family holiday at King Evelthon Beach Hotel and Resort in Chlorakas on 12 July.
The court previously heard that Foster thought the window was closed when he placed the boy on the windowsill so he could see the waterpark and "lost control" of him.
Foster held back tears as the sentence was read out by district judge Froso Christodoulidou, and hugged his lawyers and parents after the 25-minute hearing.
He told reporters outside the court: "Thank you for the support. I'm looking forward to going home and being with my wife and daughter."
Speaking through a translator, Foster's lawyer Alexandros Alexandrou said: "I met an incredible father, a very good husband and an exemplary family man with a beautiful family behind him, that support him, that embraces him, that has always been by his side with all the means that they have at their disposal."
He added that the case should never have gone to court and that proceedings had interrupted Foster's grieving.
Mr Alexandrou went on: "They (the family) need to go back (to the UK) to grieve properly and allow themselves to grieve (after) they have been in a defence mode during this procedure."
Foster's son fell nearly 40ft from a fourth-floor window, the court previously heard.
Foster, his wife and two children, and in-laws had arrived in Cyprus in the early hours of that morning, and the family had spent time in the pool before returning to their rooms to get ready for dinner.
His lawyer told the court that Foster had been enjoying "a pleasant, joyous moment of their life while on vacation" when his son noticed the waterpark.
Foster placed him on the windowsill, not realising that section of the window was open.
It was then that the "inconceivable" unfolded and the boy fell from the window in a moment that will "haunt him for the rest of his life".
The boy was pronounced dead at Paphos General Hospital, despite efforts to resuscitate him.
Foster said that "the boy fell before he had a chance to grab him" in a voluntary statement to police.
The window was 2.85m (9.3ft) wide and 1.2m (3.9ft) high, the court heard.
More from Sky News:
Homes evacuated after explosion in Belfast
Man arrested after fatal assault at caravan park in Clacton
Foster provided a blood sample at the hospital afterwards, and the alcohol concentration in his blood was estimated to be 124mg at the time of the incident, the court heard.
His lawyer said there was no testimony that he was drunk, and the alcohol consumption did not form a significant part of the case against the defendant.
Foster has no previous convictions and his remorse "is clear", the lawyer added.