Debbie Perry, the Friends actor's stepmother, made the request in a victim impact statement filed to the court ahead of the sentencing of Jasveen Sangha, known as the "Ketamine Queen", later today.
Five people, including doctors and Perry's personal assistant, have pleaded guilty to various charges connected with Perry's death. Sangha is the latest to be sentenced and prosecutors are calling for her to be jailed for at least 15 years.
In her statement to the US district court for central California, Debbie Perry said the pain caused by Perry's death "to hundreds maybe thousands" was "irreversible".
She said there is "no escape" from the thought that they will never see Perry again, and added: "You caused this."
Making a request to the court, she said: "Please give this heartless woman the maximum prison sentence so she won't be able to hurt other families like ours. Thank you."
Perry was found in his hot tub by his assistant Kenneth Iwamasa, who is due to be sentenced later this year, in October 2023. A medical examiner later ruled that ketamine and other factors had caused him to lose consciousness and drown.
Prosecutors say in court documents that Sangha "repeatedly sold dangerous drugs in high volume", that she "ran a stash house and directed others to help sell her drugs", and "obstructed justice to conceal her actions".
Perry bought large amounts of ketamine from her, including 25 vials for $6,000 (£4,464) in cash four days before his death, prosecutors previously said.
In her guilty plea last year, Sangha admitted one count of maintaining a drug-involved premises, three counts of distribution of ketamine, and one count of distribution of ketamine resulting in death or serious bodily injury.
Lawyers defending her say she has accepted responsibility for her crimes and are calling for her sentence to be no more than time already served.
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In December last year, Salvador Plasencia, a doctor, was jailed for two-and-a-half years for illegally supplying ketamine to Perry in the weeks before his death.
Another doctor, Mark Chavez, was sentenced to eight months home confinement over the fatal overdose, later in December. Erik Fleming, an associate of the actor, is due to be sentenced later this year.
Perry had struggled with addiction for years, dating back to his time on Friends, when he became one of the biggest stars of his generation playing Chandler Bing alongside Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and David Schwimmer.
The show ran for 10 seasons, from 1994 to 2004, and Perry and his castmates also appeared in the reunion show in 2021.
The animal charity said on its website that more than 250 poodle-cross dogs were found at one property earlier this year.
The numbers and living conditions of the dogs had rapidly grown out of control during extenuating family circumstances, the RSPCA added, saying it took in 87 dogs while the rest went to the Dogs Trust.
But after posting an image of the dogs crammed into a living room on Facebook last week, some commenters accused the charity of using artificial intelligence to generate it.
"We can confirm that AI has not been used to create this image", the RSCPA said on 2 April.
"As much as we wish this image wasn't real, sadly it very much is - and we are being called to more and more multi-animal reports like this.
"We don't need to use AI as we have countless stories to share about the animals our frontline teams are helping."
On Wednesday, RSPCA Superintendent Jo Hirst added: "This shocking image is the reality of many multi-animal cases, and the situation our frontline officers seem to be confronting more and more - with reports of cases involving 10, 20 and even 100 animals on the rise.
"We understand that people are so aghast they don't believe what they are seeing. But this photo is not AI - it's real. This is the staggering reality of what can happen when even well-meaning owners become overwhelmed - over-breeding can take over, and conditions can spiral out of control."
The charity said that in the last year, it had responded to 4,200 incidents which involved at least 10 animals at the same address across England and Wales.
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Meanwhile, it said it is dealing with a six-year high of animals in its care due to "rising cruelty and neglect", with almost half in emergency boarding as "many of the charity's centres are full to bursting point".
The RSPCA's AI policy states: "We will be transparent about our use of AI-generated imagery, clearly labelling any content that has been (wholly or partially) created using this technology.
"It also states that we will only use AI to accurately represent our work and our purpose. We will not use this technology to create misleading or deceptive images."
A temperature of 26.6C (79.9F) was recorded at Kew Gardens, southwest London, making it the hottest day of 2026 so far, the Met Office said.
It was the hottest day recorded in the first half of April since 1946, the forecaster added.
Wednesday's temperature beat the 24.8C (76.64F) recorded in Mona on the island of Anglesey in Wales on Tuesday, which was also the "warmest 7 April on record".
It was also hotter than temperatures recorded in some popular holiday destinations, including Ibiza and Rome.
The current warm spell is "well above" the early April average of 12C to 15C (53.6F-59F), forecasters said.
In a post on social media, the Met Office said: "For context, temperatures above 26C are very uncommon in early April.
"Indeed, today has been the second warmest day on record during the first half of any April."
The warmth is due to southerly winds, but it will turn much cooler on Thursday as a more westerly wind develops behind a cold front.
Forecasters have also been warning people to be aware of high UV and pollen levels.
The Met Office said: "It's the peak of the tree pollen season and levels of ash and birch pollen will remain very high across parts of England and Wales through the rest of the week."
Find out the forecast for your area
Many people have also been enjoying the weather for the school Easter holidays by heading to the coast.
Sky News weather producer Jo Robinson said: "This is likely to be the warmest early April spell since 2020.
"UV levels will be moderate - which may catch people out after the long winter, while the pollen count will be very high for most.
"On Thursday, temperatures will be much lower just about everywhere, but southeast England will hold onto the warmth with temperatures into the low twenties."
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The Met Office said daytime temperatures could fall by around 10C between Wednesday and Thursday ahead of "more unsettled" conditions later in the week.
Despite the warm sunshine across many parts of England, there have been cooler conditions in Northern Ireland and northwest Scotland.
The Met Office said there could also be outbreaks of rain.
Tanner Horner pleaded guilty to capital murder on the opening day of his trial in Texas for the killing of Athena Strand on Tuesday.
Horner, who abducted the girl while delivering a Christmas gift to her home in the town of Paradise, near Fort Worth in 2022, faces either the death penalty or life in prison.
Her body was found several miles from her home two days after she was reported missing, following a search involving 200 people.
Horner told investigators that he strangled Athena after accidentally hitting her with his van while making a delivery.
Athena wasn't seriously hurt after he hit her while reversing, but he panicked and put her in his van, he said.
Horner said he didn't want her to tell her father what happened, so he first tried to break the girl's neck and when that didn't work, he strangled her with his hands in the back of the van, an arrest warrant said.
He later took investigators to where he'd left Athena's body, according to the warrant.
Wise County District Attorney James Stainton dismissed Horner's version of events in his opening statement, saying the "only truthful thing that Tanner Horner told law enforcement was that he killed her".
Mr Stainton told jurors it would be hard for them to keep up with the defendant's claims, as "it is lie upon lie upon lie upon lie".
The prosecutor told the court the idea that Horner hit her with his vehicle and panicked was "an absolute lie", as the little girl was unhurt when Horner put her into the vehicle.
Mr Stainton said: "The first thing Tanner Horner says to Athena when he picks her up and puts her in that truck... he leans down and he says, 'don't scream, or I'll hurt you'."
"He says that twice."
Jurors were shown a picture of Athena taken from a video inside the delivery truck. She was still alive and sitting on her knees behind the driver's seat.
Mr Stainton said Athena fought Horner, and his DNA was found under her fingernails. He also said Horner's DNA was found "in places where you shouldn't find DNA on a seven-year-old girl".
Ashley Strand, Athena's stepmother, told jurors that the package Horner had dropped off was a Christmas present for Athena - a box of "You Can Be Anything" Barbies.
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Defence lawyer Steven Goble admitted the evidence against Horner was "overwhelming" and "terrible", but told jurors that Horner's mother drank while she was pregnant, that he has autism and suffered from "various mental illnesses throughout his life" in addition to being exposed to a "massive amount of lead".
Jurors will decide whether he will be put to death or jailed for life without parole.
Just hours after he announces a ceasefire with Iran - we speak to Donald Trump on the phone.
What did he say? We push him on the many questions plaguing his negotiations with the Iranians.
Mark Stone and Martha Kelner digest.
You can watch all episodes on our YouTube channel.
Email us on trump100@sky.uk with your comments and questions.