Having normal blood pressure, no diabetes, and not smoking from age 45 to 65 keeps dementia at bay for well over a decade, research suggests.
Experts from New York University Langone Health studied more than 12,000 people who were free of dementia when they were aged 55.
Subjects were assessed for three key things affecting dementia risk - high blood pressure, diabetes, and smoking, and followed for an average of 26 years.
Just over 3,000 people developed dementia, while roughly 5,200 people died without developing the illness.
Those who had none of the three risk factors lived without developing dementia nearly 13 years longer than those who had all three.
Non-smokers who didn't have diabetes or high blood pressure when the study started at age 55, lived for another 30.1 years dementia-free, the authors found.
Meanwhile, those with one risk factor survived another 26.3 years without dementia, those with two had 21 years, and those with three had just over 17 years.
Dr Josef Coresh, director of the Optimal Aging Institute at NYU Langone, said the findings suggest people "need to actively avert these factors in midlife as a strategy for preserving brain health for more than a decade".
Lifestyle choices, especially in midlife, can reduce the risk of developing dementia, according to previous research, with exercise, not smoking, watching alcohol intake, and not being socially isolated among the factors highlighted.
The new study said: "Individuals with no midlife vascular risk factors lived an average of 13 more dementia-free survival years compared to those with three risk factors."
The study also found that, no matter how many risk factors they had, women lived longer without dementia than men, and white people had more dementia-free years than black people.
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Dr Sonya Miller, of TauRx Therapeutics Management, said brain health "is as important as physical health, and the two cannot be separated".
She continued: "With dementia now being the nation's number one cause of death, we all need to take our brain health seriously and make the changes we can on an individual basis."
Dr Jacqui Hanley, head of research funding at Alzheimer's Research UK, said: "While there is no guaranteed way to prevent dementia, research, including this study, suggests that addressing risk factors for poor cardiovascular health may also help reduce the risk of cognitive decline and dementia.
Professor Ian Maidment, from Aston University, said the research "adds to the evidence, from multiple studies, that what is good for the heart is good for the brain.
"Not smoking, having blood pressure within the normal range, and avoiding diabetes delayed the onset of dementia for over 10 years."
Reports emerged of a flying object at Leipzig/Halle late on Tuesday night and closed both runways while an anti-explosives robot was sent to check an object near the southern runway.
The discovery shows that the explosives-packed drone represents a new type of "hybrid attack", the German interior minister said.
Police and prosecutors said they found the drone with "an unknown explosive device" and that experts had removed its detonator.
Photos showed police and the robot near one of Ukraine's huge Antonov cargo jets. Germany's Bild news site said the drone was found lying close to the plane.
The Antonov jets are famous for their huge size, with one of the most famous examples destroyed in the early days of the Ukraine war.
German airports are on high alert after a series of drone sightings over sensitive sites – including military facilities, energy terminals, seaports and logistics companies.
'A new quality of threat'
Counter-terror officers are investigating, and interior minister Alexander Dobrindt held an emergency with Germany's security services on Wednesday night.
At a press conference, he described the incident as a "very serious, security-relevant incident" and a "hybrid attack scenario".
Mr Dobrindt added: "This drone was equipped with explosives. That represents a new quality of threat.
"Drone sightings, drones, and threats are also in a hybrid context – we're familiar with that from the past. But a drone, armed with explosives, being present on airport grounds – that is a new threat scenario.
"We are dealing with a high level of danger. These threats are not being carried out by amateurs. A high degree of technical experience must be involved. Experience in handling explosives must also be present.
"We are talking here about a professional, hybrid threat, one that we will continue to have to deal with."
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Meanwhile, another cargo aircraft – believed to be owned by DHL – was hit by an object as it climbed away from Leipzig after diverting last night.
Slight damage was found to the plane when it landed in Hannover. Investigations into the object's origins are ongoing.
It comes after an investigation found a number of incendiary devices had been hidden in parcels that caught fire in 2024, including one incident at a DHL depot in Birmingham.
Western security services blamed Russian intelligence, though the country denied responsibility for those incidents, as well as for the recent drone sightings.
Leipzig – a key cargo hub in eastern Germany – reopened its northern runway about two hours after the security alert. The southern runway was scheduled to close for maintenance on Wednesday.
The killer, who is also 16, was convicted by a jury at Hove Crown Court on Wednesday, of stabbing Joshua Ingram to death in Seaford, East Sussex, in September last year.
The juvenile defendant, who cannot be named due to his age, pleaded guilty to manslaughter but denied murder, claiming he stabbed Joshua in a "tragic and reckless moment".
There were gasps from the public gallery, where Joshua's parents and family were sitting, as the murder verdict was read out.
The defendant was on trial alongside two other boys, aged 17 and 15, who were accused of conspiracy to cause grievous bodily harm with intent in the lead-up to the stabbing.
Jurors found all three of them not guilty of that charge.
The 15-year-old was found guilty of assisting an offender on the day of the murder and the 17-year-old had already pleaded guilty to the same offence.
The knife attack took place when the teenage killer went to Seaford station with a 19cm knife hidden in his tracksuit bottoms, then approached Joshua and stabbed him twice.
The blade went 15cm into Joshua's body, medical experts told jurors during the trial.
In a statement following the verdict, Joshua's family described him as a "cheeky chappy" who was two days into a brick laying course at college.
"This is a future life he will now never achieve. As a family, our lives changed forever that evening," his family, including his mother, Yvette Bullen, and father, Dave Ingram, said.
"We hope Josh's story serves as a reminder of the devastating consequences of knife crime.
"This reckless behaviour devastates countless lives.
"So we urge young people to rethink, choose a different path in life, to avoid another family going through the pain and suffering we have, and will continue to do so for the rest of our lives."
'He stood no chance'
Prosecutor Rossano Scamardella KC said the 16-year-old defendant was a "small-time drug dealer" who had supplied Joshua with drugs in the summer of 2025, but had not been paid for them.
"Joshua stood no chance. The speed of the attack from behind gave him no chance to defend himself and the injury he sustained was so serious that he could not survive," he told the court.
"He collapsed on the station platform and despite the very best attempts by members of the public and emergency workers, he died within an hour of being stabbed and even before he could be taken to hospital."
He added: "All of this over a £20 cannabis debt."
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The boy told jurors he viewed the 19cm knife as an "accessory" which he had bought on Telegram but "didn't look at it for what it actually was" and never intended to kill or seriously harm Joshua.
The court also heard the teenager had the knife used to kill Joshua since he was in Year 9 and would "wave it around and playfully intimidate" people with it at his house.
Giving evidence in the trial, a friend of Joshua's who was with him when he was stabbed, said he saw the attacker "with no hesitation".
The friend said the defendant asked, "is that Josh?", before he stepped ahead of him, pulled a knife from his right hip and "went for it twice" and ran.
He said: "He had no hesitation - he had a very still facial expression, he wasn't pulling a face, he didn't look like he had anger in him.
"He looked very calm and just normal, but then just did that. I don't think Josh even knew what had happened."
The friend described how Joshua walked a couple of steps and then "dropped to the floor" as he tried to call 999.
Detective Chief Inspector Paul Stanley, of the British Transport Police, said the jury saw through the defendant's attempts to "diminish his actions" and dismiss messages about harming Joshua as "sheer bravado".
"But following a chance meeting on that fateful day, he put his talk into action, taking Joshua's life with a singular blow and a large knife he routinely carried," he said.
The defendant will be sentenced on 2 October.
A number of autonomous pure electric Ford Mustang Mach-E vehicles were approved for private hire vehicle (PHV) licences by Transport for London (TfL), Wayve said on Wednesday.
Uber, which will operate the vehicles, said that, ahead of a full public launch, rides would be offered "later this summer" to some of the 100,000 people who signed up to express their interest in trying robotaxis.
There will, however, be a human driver sitting behind the wheel ready to take control during journeys.
If and when the technology is shown to be safe, Uber and Wayve will need to obtain separate approval from the Driver and Vehicle Standards Agency if they want to operate the cars without a driver.
Wayve vice president for global affairs and assurance, Sarah Gates, called the granting of the licences "an important step towards giving Londoners the chance to experience autonomous driving technology".
She said: "The responsible deployment of these vehicles will bring us safer, cleaner and quieter streets, and we're proud to continue working alongside regulators, communities, and the public as we take the next steps towards making autonomous rides a reality in the capital".
Uber global head of autonomous mobility operations Annie Duvnjak described the occasion as a "key milestone in bringing autonomous rides to London on Uber".
She said: "Our interest list has seen an incredible response from Londoners who are excited to experience Wayve's British-built autonomous driving technology."
A TfL spokesperson said safety is its "top priority", adding that any new vehicle licensed to carry passengers in the city must align with its target of eliminating all deaths and serious injuries on London's roads by 2041.
Wayve's modifications to the Mustang Mach-E - such as its six cameras - were assessed by experts who found "they do not compromise passenger safety", the spokesperson added.
A qualified driver must be present and remain responsible for the car under the terms of a PHV licence.
Matthew Wright, regional organiser for the GMB Union, which represents thousands of private hire drivers in London, described TfL's decision as "a worrying development".
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He said: "We can't go charging ahead with new technologies without considering the implications of autonomous vehicles on all parties."
These include how drivers will be "supported to reskill and redeploy if their jobs go", and how driverless cars "cannot replace the knowledge, experience and human connection that a skilled driver offers".
London will be the first city in the world to use Wayve's technology for commercial journeys.
The company is also working with car manufacturers such as Nissan and Stellantis to deploy its systems in private vehicles.
Police Scotland said officers were called to Elliot Industrial Estate in Arbroath at about 12.02am on Monday after Minnie Merriman was discovered.
The youngster was taken to Ninewells Hospital in Dundee, where she later died.
Christopher Rice, 35, was arrested and charged in connection with her death.
The force previously confirmed the pair were "known" to each other and other members of the family, from West Yorkshire, had been camping in the area.
Rice appeared before Forfar Sheriff Court on Wednesday, where he made no plea to the single charge of murder. The suspect, of Wakefield in West Yorkshire, was remanded in custody and is due back in the dock within the next eight days.
Police Scotland earlier said the other members of the family are being supported by specialist officers.
In a statement released through the force, Minnie's family said: "We are devastated with the loss of our beloved, absolutely incredible, beautiful and brave Minnie Moo.
"Our family asks that our privacy is respected at this extremely difficult time."
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Detective Inspector Mike Ness, of the major investigation team, said inquiries into the incident remain ongoing.
He said: "Our thoughts remain with everyone affected by these events, especially Minnie's family.
"A police presence will remain in the area while our inquiries continue.
"Anyone with any concerns, or information, should approach these officers or contact Police Scotland on 101."
It is understood West Yorkshire Police is supporting Police Scotland's investigation.